Bi-Functional Radiotheranostics of <sup>188</sup>Re-Liposome-Fcy-hEGF for Radio- and Chemo-Therapy of EGFR-Overexpressing Cancer Cells

Bi-Functional Radiotheranostics of <sup>188</sup>Re-Liposome-Fcy-hEGF for Radio- and Chemo-Therapy of EGFR-Overexpressing Cancer Cells

Epidermal growth factor receptor (EGFR) specific therapeutics is of great importance in cancer treatment. Fcy-hEGF fusion protein, composed of yeast cytosine deaminase (Fcy) and human EGF (hEGF), is capable of binding to EGFR and enzymatically convert 5-fluorocytosine (5-FC) to 1000-fold toxic 5-flu...

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Bibliographic Details
Main Authors: Yi-Shu Huang, Wei-Chuan Hsu, Chien-Hong Lin, Sheng-Nan Lo, Chu-Nian Cheng, Ming-Syuan Lin, Te-Wei Lee, Chih-Hsien Chang, Keng-Li Lan
Format: Article
Language:English
Published: MDPI AG 2021-02-01
Series:International Journal of Molecular Sciences
Subjects:
cytosine deaminase
epidermal growth factor receptor
5-fluorocuracil
liposome
prodrug
rhenium-188
Online Access:https://www.mdpi.com/1422-0067/22/4/1902

Internet

https://www.mdpi.com/1422-0067/22/4/1902

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