Dexibuprofen prevents neurodegeneration and cognitive decline in APPswe/PS1dE9 through multiple signaling pathways

Dexibuprofen prevents neurodegeneration and cognitive decline in APPswe/PS1dE9 through multiple signaling pathways

The aim of the present study is to elucidate the neuronal pathways associated to NSAIDs causing a reduction of the risk and progression of Alzheimer's disease. The research was developed administering the active enantiomer of ibuprofen, dexibuprofen (DXI), in order to reduce associated gastric...

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Bibliographic Details
Main Authors: Miren Ettcheto, Elena Sánchez-López, Laura Pons, Oriol Busquets, Jordi Olloquequi, Carlos Beas-Zarate, Merce Pallas, Maria Luisa García, Carme Auladell, Jaume Folch, Antoni Camins
Format: Article
Language:English
Published: Elsevier 2017-10-01
Series:Redox Biology
Subjects:
APPSwe/PS1dE9
Dexibuprofen
Insulin receptor
Mitochondria
Hippocampus
TAU
Memory impairment
Alzheimer's disease
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231717302823

Internet

http://www.sciencedirect.com/science/article/pii/S2213231717302823

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