SIRT5 deficiency enhances the proliferative and therapeutic capacities of adipose‐derived mesenchymal stem cells via metabolic switching

SIRT5 deficiency enhances the proliferative and therapeutic capacities of adipose‐derived mesenchymal stem cells via metabolic switching

Abstract Background Mesenchymal stem cells (MSCs) have therapeutic potential for multiple ischemic diseases. However, in vitro expansion of MSCs before clinical application leads to metabolic reprogramming from glycolysis to oxidative phosphorylation, drastically impairing their proliferative and th...

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Bibliographic Details
Main Authors: Tiantong Ou, Wenlong Yang, Wenjia Li, Yijing Lu, Zheng Dong, Hongming Zhu, Xiaolei Sun, Zhen Dong, Xinyu Weng, Suchi Chang, Hua Li, Yufan Li, Zhiwei Qiu, Kai Hu, Aijun Sun, Junbo Ge
Format: Article
Language:English
Published: Wiley 2020-09-01
Series:Clinical and Translational Medicine
Subjects:
adipose‐derived mesenchymal stem cells
cell proliferation
hind limb ischemia
metabolic switching
SIRT5
Online Access:https://doi.org/10.1002/ctm2.172

Internet

https://doi.org/10.1002/ctm2.172

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