Impairment of Cerebrovascular Hemodynamics in Patients With Severe and Milder Forms of Sickle Cell Disease

Impairment of Cerebrovascular Hemodynamics in Patients With Severe and Milder Forms of Sickle Cell Disease

In patients with sickle cell disease (SCD), cerebral blood flow (CBF) is elevated to counteract anemia and maintain oxygen supply to the brain. This may exhaust the vasodilating capacity of the vessels, possibly increasing the risk of silent cerebral infarctions (SCI). To further investigate cerebro...

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Bibliographic Details
Main Authors: Liza Afzali-Hashemi, Koen P. A. Baas, Anouk Schrantee, Bram F. Coolen, Matthias J. P. van Osch, Stefan M. Spann, Erfan Nur, John C. Wood, Bart J. Biemond, Aart J. Nederveen
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-04-01
Series:Frontiers in Physiology
Subjects:
vascular reactivity
sickle cell anaemia
arterial spin label (ASL) MRI
cerebral blood flow
cerebrovascular reactivity
hemodynamic abnormalities
Online Access:https://www.frontiersin.org/articles/10.3389/fphys.2021.645205/full

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https://www.frontiersin.org/articles/10.3389/fphys.2021.645205/full

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