PARP inhibitor resistance: the underlying mechanisms and clinical implications

PARP inhibitor resistance: the underlying mechanisms and clinical implications

Abstract Due to the DNA repair defect, BRCA1/2 deficient tumor cells are more sensitive to PARP inhibitors (PARPi) through the mechanism of synthetic lethality. At present, several PAPRi targeting poly (ADP-ribose) polymerase (PARP) have been approved for ovarian cancer and breast cancer indications...

Full description

Bibliographic Details
Main Authors: He Li, Zhao-Yi Liu, Nayiyuan Wu, Yong-Chang Chen, Quan Cheng, Jing Wang
Format: Article
Language:English
Published: BMC 2020-06-01
Series:Molecular Cancer
Subjects:
PARPi
Homologous recombination
Resistance
Synthetic lethality
Online Access:http://link.springer.com/article/10.1186/s12943-020-01227-0

Internet

http://link.springer.com/article/10.1186/s12943-020-01227-0

Similar Items