The Marine-Derived Natural Product Epiloliolide Isolated from <i>Sargassum horneri</i> Regulates NLRP3 via PKA/CREB, Promoting Proliferation and Anti-Inflammatory Effects of Human Periodontal Ligament Cells

The Marine-Derived Natural Product Epiloliolide Isolated from <i>Sargassum horneri</i> Regulates NLRP3 via PKA/CREB, Promoting Proliferation and Anti-Inflammatory Effects of Human Periodontal Ligament Cells

Currently, periodontitis treatment relies on surgical operations, anti-inflammatory agents, or antibiotics. However, these treatments cause pain and side effects, resulting in a poor prognosis. Therefore, in this study, we evaluated the impact of the compound epiloliolide isolated from <i>Sarg...

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Bibliographic Details
Main Authors: Eun-Nam Kim, Woguti Yvonne Nabende, Hyeyoon Jeong, Dongyup Hahn, Gil-Saeng Jeong
Format: Article
Language:English
Published: MDPI AG 2021-07-01
Series:Marine Drugs
Subjects:
<i>Sargassum horneri</i>
periodontitis
protein kinase A (PKA)
cAMP-responsive element-binding protein (CREB)
epiloliolide
Online Access:https://www.mdpi.com/1660-3397/19/7/388

Internet

https://www.mdpi.com/1660-3397/19/7/388

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