Dependence of Tumor Cell Lines and Patient-Derived Tumors on the NAD Salvage Pathway Renders Them Sensitive to NAMPT Inhibition with GNE-618

Dependence of Tumor Cell Lines and Patient-Derived Tumors on the NAD Salvage Pathway Renders Them Sensitive to NAMPT Inhibition with GNE-618

Nicotinamide adenine dinucleotide (NAD) is a critical metabolite that is required for a range of cellular reactions. A key enzyme in the NAD salvage pathway is nicotinamide phosphoribosyl transferase (NAMPT), and here, we describe GNE-618, an NAMPT inhibitor that depletes NAD and induces cell death...

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Bibliographic Details
Main Authors: Yang Xiao, Kristi Elkins, Jenni K Durieux, Leslie Lee, Jason Oeh, Lulu X Yang, Xiaorong Liang, Chris DelNagro, Jarrod Tremayne, Mandy Kwong, Bianca M Liederer, Peter K Jackson, Lisa D Belmont, Deepak Sampath, Thomas O'Brien
Format: Article
Language:English
Published: Elsevier 2013-10-01
Series:Neoplasia: An International Journal for Oncology Research
Online Access:http://www.sciencedirect.com/science/article/pii/S1476558613801054

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http://www.sciencedirect.com/science/article/pii/S1476558613801054

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