A novel single-domain antibody multimer that potently neutralizes tetanus neurotoxin

Tetanus antitoxin, produced in animals, has been used for the prevention and treatment of tetanus for more than 100 years. The availability of antitoxins, ethical issues around production, and risks involved in the use of animal derived serum products are a concern. We therefore developed a llama de...

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Bibliographic Details
Main Authors: Hans de Smit, Bart Ackerschott, Robert Tierney, Paul Stickings, Michiel M. Harmsen
Format: Article
Language:English
Published: Elsevier 2021-08-01
Series:Vaccine: X
Subjects:
VHH
Online Access:http://www.sciencedirect.com/science/article/pii/S2590136221000164