Hepatitis B virus X protein promotes vimentin expression via LIM and SH3 domain protein 1 to facilitate epithelial-mesenchymal transition and hepatocarcinogenesis

Hepatitis B virus X protein promotes vimentin expression via LIM and SH3 domain protein 1 to facilitate epithelial-mesenchymal transition and hepatocarcinogenesis

Abstract Background Hepatitis B virus (HBV) X protein (HBX) has been reported to be responsible for the epithelial-mesenchymal transition (EMT) in HBV-related hepatocellular carcinoma (HCC). Vimentin is an EMT-related molecular marker. However, the importance of vimentin in the pathogenesis of HCC m...

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Bibliographic Details
Main Authors: Hongjuan You, Dongchen Yuan, Yanwei Bi, Ning Zhang, Qi Li, Tao Tu, Xiao Wei, Qi Lian, Tong Yu, Delong Kong, Xiaoying Yang, Xiangye Liu, Xiaomei Liu, Fanyun Kong, Kuiyang Zheng, Renxian Tang
Format: Article
Language:English
Published: BMC 2021-03-01
Series:Cell Communication and Signaling
Subjects:
Hepatocellular carcinoma
HBX
Vimentin
LASP1
Epithelial-mesenchymal transition
Online Access:https://doi.org/10.1186/s12964-021-00714-1

Internet

https://doi.org/10.1186/s12964-021-00714-1

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