(+)-Usnic Acid Induces ROS-dependent Apoptosis via Inhibition of Mitochondria Respiratory Chain Complexes and Nrf2 Expression in Lung Squamous Cell Carcinoma

(+)-Usnic Acid Induces ROS-dependent Apoptosis via Inhibition of Mitochondria Respiratory Chain Complexes and Nrf2 Expression in Lung Squamous Cell Carcinoma

Lung squamous cell carcinoma (LUSC) has a poor prognosis, in part due to poor therapeutic response and limited therapeutic alternatives. Lichens are symbiotic organisms, producing a variety of substances with multiple biological activities. (+)-Usnic acid, an important biologically active metabolite...

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Bibliographic Details
Main Authors: Wanchen Qi, Changpeng Lu, Huiliang Huang, Weinan Zhang, Shaofei Song, Bing Liu
Format: Article
Language:English
Published: MDPI AG 2020-01-01
Series:International Journal of Molecular Sciences
Subjects:
(+)-usnic acid
lung squamous cell carcinoma
reactive oxygen species (ros)
paclitaxel
Online Access:https://www.mdpi.com/1422-0067/21/3/876

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https://www.mdpi.com/1422-0067/21/3/876

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