Diastereoselective Spiroannulation of Phenolic Substrates: Advances Towards the Asymmetric Formation of the Manumycin m-C7N Core Skeleton

Diastereoselective Spiroannulation of Phenolic Substrates: Advances Towards the Asymmetric Formation of the Manumycin m-C7N Core Skeleton

The asymmetric syntheses of two new spirolactones prepared in optically pure form from L-3-nitrotyrosine are described. The key step, an oxidative spiroannulation, was carried out on the optically active phenols 11a and 11b and afforded the new spirolactones 5a and 5b in 85% and 83% yields, respecti...

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Bibliographic Details
Main Authors: Thomas W. Scully, Jolene S. Kwasnitza, Randy R. Spaetzel, Guy L. Plourde
Format: Article
Language:English
Published: MDPI AG 2007-09-01
Series:Molecules
Subjects:
Spiroannulation
oxidation
phenol
diastereoselective
asymmetric
Manumycins
Aranorosins
Gymnastatins.
Online Access:http://www.mdpi.com/1420-3049/12/9/2215/

Internet

http://www.mdpi.com/1420-3049/12/9/2215/

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