Critical Roles of PIWIL1 in Human Tumors: Expression, Functions, Mechanisms, and Potential Clinical Implications

Critical Roles of PIWIL1 in Human Tumors: Expression, Functions, Mechanisms, and Potential Clinical Implications

P-element-induced wimpy testis (PIWI)-interacting RNAs (piRNAs) are a class of small non-coding RNA molecules that are 24–31 nucleotides in length. PiRNAs are thought to bind to PIWI proteins (PIWL1-4, a subfamily of Argonaute proteins), forming piRNA/PIWI complexes that influence gene expression at...

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Bibliographic Details
Main Authors: Peixin Dong, Ying Xiong, Yosuke Konno, Kei Ihira, Daozhi Xu, Noriko Kobayashi, Junming Yue, Hidemichi Watari
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-02-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
piRNA
PIWIL1
HIWI
tumorigenesis
cancer metastasis
prognostic biomarker
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2021.656993/full

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https://www.frontiersin.org/articles/10.3389/fcell.2021.656993/full

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