Intermittent Ethanol during Adolescence Leads to Lasting Behavioral Changes in Adulthood and Alters Gene Expression and Histone Methylation in the PFC

Adolescents primarily consume alcohol in binges, which can be particularly harmful to the developing frontal cortex and increase risk for an adult alcohol use disorder. We conducted a study investigating immediate and long lasting changes to the prefrontal cortex (PFC) transcriptome to determine the...

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Bibliographic Details
Main Authors: Jennifer T. Wolstenholme, Tariq Mahmood, Guy M. Harris, Shahroze Abbas, Michael F. Miles
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-09-01
Series:Frontiers in Molecular Neuroscience
Subjects:
Online Access:http://journal.frontiersin.org/article/10.3389/fnmol.2017.00307/full