Rapamycin Attenuates High Glucose-Induced Inflammation Through Modulation of mTOR/NF-κB Pathways in Macrophages

Rapamycin Attenuates High Glucose-Induced Inflammation Through Modulation of mTOR/NF-κB Pathways in Macrophages

Background: The NLRP3 inflammasome is one of the key contributors to impaired wound healing in diabetes. In this study, we assessed the role of rapamycin on high glucose-induced inflammation in THP-1-derived macrophages and investigated the underlying signaling mechanisms.Methods: THP-1-derived macr...

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Bibliographic Details
Main Authors: Jiezhi Dai, Chaoyin Jiang, Hua Chen, Yimin Chai
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-10-01
Series:Frontiers in Pharmacology
Subjects:
diabetic wound
NLRP3 inflammasome
mTOR
NF-κB
Rapamycin
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2019.01292/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2019.01292/full

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