Aspirin Induces Apoptosis through Release of Cytochrome c from Mitochondria

Aspirin Induces Apoptosis through Release of Cytochrome c from Mitochondria

Nonsteroidal anti-inflammatory drugs (NSAID) reduce the risk for cancer, due to their anti proliferative and apoptosis-inducing effects. A critical pathway for apoptosis involves the release of cytochrome c from mitochondria, which then interacts with Apaf-1 to activate caspase proteases that orche...

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Bibliographic Details
Main Authors: Katja C. Zimmermann, Nigel J. Waterhouse, Joshua C. Goldstein, Martin Schuler, Douglas R. Green
Format: Article
Language:English
Published: Elsevier 2000-01-01
Series:Neoplasia: An International Journal for Oncology Research
Subjects:
aspirin
apoptosis
cytochrome c
mitochondria
NSAID
Online Access:http://www.sciencedirect.com/science/article/pii/S147655860080041X

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http://www.sciencedirect.com/science/article/pii/S147655860080041X

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