Central Alteration in Peripheral Neuropathy of Trembler-J Mice: Hippocampal pmp22 Expression and Behavioral Profile in Anxiety Tests

Central Alteration in Peripheral Neuropathy of Trembler-J Mice: Hippocampal pmp22 Expression and Behavioral Profile in Anxiety Tests

Charcot–Marie–Tooth (CMT) type 1 disease is the most common human hereditary demyelinating neuropathy. Mutations in pmp22 cause about 70% of all CMT1. Trembler-J (TrJ/+) mice are an animal model of CMT1E, having the same spontaneous pmp22 mutation that is found in humans. We compared the behavior pr...

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Bibliographic Details
Main Authors: Juan Pablo Damián, Lucia Vázquez Alberdi, Lucía Canclini, Gonzalo Rosso, Silvia Olivera Bravo, Mariana Martínez, Natalia Uriarte, Paul Ruiz, Miguel Calero, María Vittoria Di Tomaso, Alejandra Kun
Format: Article
Language:English
Published: MDPI AG 2021-04-01
Series:Biomolecules
Subjects:
Charcot–Marie–Tooth
hippocampus
peripheral-myelin-protein-22
anxiety
Trembler-J
CA3 neurons
Online Access:https://www.mdpi.com/2218-273X/11/4/601

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https://www.mdpi.com/2218-273X/11/4/601

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