NAD+ supplement potentiates tumor-killing function by rescuing defective TUB-mediated NAMPT transcription in tumor-infiltrated T cells

NAD+ supplement potentiates tumor-killing function by rescuing defective TUB-mediated NAMPT transcription in tumor-infiltrated T cells

Summary: Although tumor-infiltrating lymphocytes (TILs) maintain their ability to proliferate, persist, and eradicate tumors, they are frequently dysfunctional in situ. By performing both whole-genome CRISPR and metabolic inhibitor screens, we identify that nicotinamide phosphoribosyltransferase (NA...

Full description

Bibliographic Details
Main Authors: Yuetong Wang, Fei Wang, Lihua Wang, Shizhen Qiu, Yufeng Yao, Chenxu Yan, Xuexue Xiong, Xuyong Chen, Quanquan Ji, Jian Cao, Ganglong Gao, Dake Li, Liye Zhang, Zhiqian Guo, Ruoning Wang, Haopeng Wang, Gaofeng Fan
Format: Article
Language:English
Published: Elsevier 2021-08-01
Series:Cell Reports
Subjects:
T cell activation
NAMPT
TUB
NAD+ supplement
CAR-T
PD-1
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124721009463

Internet

http://www.sciencedirect.com/science/article/pii/S2211124721009463

Similar Items