Cell-Selective Regulation of CFTR Gene Expression: Relevance to Gene Editing Therapeutics

Cell-Selective Regulation of CFTR Gene Expression: Relevance to Gene Editing Therapeutics

The cystic fibrosis transmembrane conductance regulator (CFTR) gene is an attractive target for gene editing approaches, which may yield novel therapeutic approaches for genetic diseases such as cystic fibrosis (CF). However, for gene editing to be effective, aspects of the three-dimensional (3D) st...

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Bibliographic Details
Main Authors: Hannah Swahn, Ann Harris
Format: Article
Language:English
Published: MDPI AG 2019-03-01
Series:Genes
Subjects:
CFTR
cis-regulatory elements
enhancers
chromatin architecture
transcription factors
gene editing
CRISPR/Cas9
Online Access:http://www.mdpi.com/2073-4425/10/3/235

Internet

http://www.mdpi.com/2073-4425/10/3/235

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