Virtual memory cells make a major contribution to the response of aged influenza-naïve mice to influenza virus infection

Virtual memory cells make a major contribution to the response of aged influenza-naïve mice to influenza virus infection

Abstract Background A diverse repertoire of naïve T cells is thought to be essential for a robust response to new infections. However, a key aspect of aging of the T cell compartment is a decline in numbers and diversity of peripheral naïve T cells. We have hypothesized that the age-related decline...

Full description

Bibliographic Details
Main Authors: Kathleen G. Lanzer, Tres Cookenham, William W. Reiley, Marcia A. Blackman
Format: Article
Language:English
Published: BMC 2018-08-01
Series:Immunity & Ageing
Subjects:
T cell receptor repertoire
Virtual memory (VM) T cells
True memory (TM) T cells
Influenza
Ageing
Mouse model
Online Access:http://link.springer.com/article/10.1186/s12979-018-0122-y

Internet

http://link.springer.com/article/10.1186/s12979-018-0122-y

Similar Items