Functional and Homeostatic Impact of Age-Related Changes in Lymph Node Stroma

Adults over 65 years of age are more vulnerable to infectious disease and show poor responses to vaccination relative to those under 50. A complex set of age-related changes in the immune system is believed to be largely responsible for these defects. These changes, collectively termed immune senesc...

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Bibliographic Details
Main Authors: Heather L. Thompson, Megan J. Smithey, Charles D. Surh, Janko Nikolich-Žugich
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-06-01
Series:Frontiers in Immunology
Subjects:
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2017.00706/full