Optimization of ultrastructural preservation of human brain for transmission electron microscopy after long post-mortem intervals

Optimization of ultrastructural preservation of human brain for transmission electron microscopy after long post-mortem intervals

Abstract Electron microscopy (EM) provides the necessary resolution to visualize the finer structures of nervous tissue morphology, which is important to understand healthy and pathological conditions in the brain. However, for the interpretation of the micrographs the tissue preservation is crucial...

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Bibliographic Details
Main Authors: Mariella Sele, Stefan Wernitznig, Saška Lipovšek, Snježana Radulović, Johannes Haybaeck, Anna Maria Birkl-Toeglhofer, Christina Wodlej, Florian Kleinegger, Stephan Sygulla, Marlene Leoni, Stefan Ropele, Gerd Leitinger
Format: Article
Language:English
Published: BMC 2019-09-01
Series:Acta Neuropathologica Communications
Subjects:
Electron microscopy
High pressure freezing
Freeze substitution
Post-mortem interval
Human brain
Online Access:http://link.springer.com/article/10.1186/s40478-019-0794-3

Internet

http://link.springer.com/article/10.1186/s40478-019-0794-3

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