A Molecular Clock Infers Heterogeneous Tissue Age Among Patients with Barrett's Esophagus.

Biomarkers that drift differentially with age between normal and premalignant tissues, such as Barrett's esophagus (BE), have the potential to improve the assessment of a patient's cancer risk by providing quantitative information about how long a patient has lived with the precursor (i.e....

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Bibliographic Details
Main Authors: Kit Curtius, Chao-Jen Wong, William D Hazelton, Andrew M Kaz, Amitabh Chak, Joseph E Willis, William M Grady, E Georg Luebeck
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2016-05-01
Series:PLoS Computational Biology
Online Access:https://doi.org/10.1371/journal.pcbi.1004919