Bile acids elicited endothelium-dependent vasoconstrictor hypo-activity through TRPV4 channels in the thoracic aorta of bile duct ligation rats

Bile acids elicited endothelium-dependent vasoconstrictor hypo-activity through TRPV4 channels in the thoracic aorta of bile duct ligation rats

Numerous studies have demonstrated the impaired cardiovascular reactivity in cholestasis patients and bile duct ligated animals. However, the underlying mechanism remains uncertain. Transient receptor potential cation V4 (TRPV4) channels are reported to be naturally expressed in the cardiovascular s...

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Bibliographic Details
Main Authors: Hong-Qian Wang, Xiao-Yan Meng, Mo Chen, Sai-hong Xu, Mei Zhu, Xu Lu, Fei-Xiang Wu, Wei-Feng Yu
Format: Article
Language:English
Published: Elsevier 2019-01-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Transient receptor potential cation channel V4
Bile acids
Aorta
Cyclooxygenase 2
Bile duct ligation
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332218346006

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http://www.sciencedirect.com/science/article/pii/S0753332218346006

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