Targeting cytokine signaling checkpoint CIS activates NK cells to protect from tumor initiation and metastasis

Targeting cytokine signaling checkpoint CIS activates NK cells to protect from tumor initiation and metastasis

The cytokine-induced SH2-containing protein CIS belongs to the suppressor of cytokine signaling (SOCS) protein family. Here, we show the critical role of CIS in suppressing natural killer (NK) cell control of tumor initiation and metastasis. Cish-deficient mice were highly resistant to methylcholant...

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Bibliographic Details
Main Authors: Eva M. Putz, Camille Guillerey, Kevin Kos, Kimberley Stannard, Kim Miles, Rebecca B. Delconte, Kazuyoshi Takeda, Sandra E. Nicholson, Nicholas D. Huntington, Mark J. Smyth
Format: Article
Language:English
Published: Taylor & Francis Group 2017-02-01
Series:OncoImmunology
Subjects:
cancer
cytokine signaling
immunotherapy
metastasis
nk cells
Online Access:http://dx.doi.org/10.1080/2162402X.2016.1267892

Internet

http://dx.doi.org/10.1080/2162402X.2016.1267892

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