Emergence of a Large-Plaque Variant in Mice Infected with Coxsackievirus B3

Coxsackieviruses are enteric viruses that frequently infect humans. To examine coxsackievirus pathogenesis, we orally inoculated mice with the coxsackievirus B3 (CVB3) Nancy strain. Using HeLa cell plaque assays with agar overlays, we noticed that some fecal viruses generated plaques >100 times a...

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Bibliographic Details
Main Authors: Yao Wang, Julie K. Pfeiffer
Format: Article
Language:English
Published: American Society for Microbiology 2016-03-01
Series:mBio
Online Access:http://mbio.asm.org/cgi/content/full/7/2/e00119-16