Chronic pyruvate supplementation increases exploratory activity and brain energy reserves in young and middle-aged mice

Chronic pyruvate supplementation increases exploratory activity and brain energy reserves in young and middle-aged mice

Numerous studies have reported neuroprotective effects of pyruvate when given in systemic injections. Impaired glucose uptake and metabolism are found in Alzheimer's disease (AD) and in AD mouse models. We tested whether dietary pyruvate supplementation is able to provide added energy supply to...

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Bibliographic Details
Main Authors: Hennariikka eKoivisto, Henri eLeinonen, Mari ePuurula, Hani S Hafez, Glenda eAlquicer Barrera, Malin H Stridh, Helle S Waagepetersen, Mika eTiainen, Pasi eSoininen, Yuri eZilberter, Heikki eTanila
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-03-01
Series:Frontiers in Aging Neuroscience
Subjects:
Aging
Glycogen
Memory
Alzheimer’s disease
explorative activity
Online Access:http://journal.frontiersin.org/Journal/10.3389/fnagi.2016.00041/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fnagi.2016.00041/full

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