Enhancement of Pneumocandin B0 Production in Glarea lozoyensis by Low-Temperature Adaptive Laboratory Evolution

Enhancement of Pneumocandin B0 Production in Glarea lozoyensis by Low-Temperature Adaptive Laboratory Evolution

The production of pneumocandin B0 is limited by feedback inhibition. Here, low-temperature adaptive laboratory evolution (ALE) was used to improve the production capacity of Glarea lozoyensis by enhancing its membrane permeability. After 50 cycles of ALE, the pneumocandin B0 production of the endpoi...

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Bibliographic Details
Main Authors: Ping Song, Ke Zhang, Sen Zhang, Bao-Qi Huang, Xiao-Jun Ji, Lu-Jing Ren, Song Gao, Jian-Ping Wen, He Huang
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-11-01
Series:Frontiers in Microbiology
Subjects:
fatty acid synthesis regulation
membrane permeability
adaptive evolution
enzyme activity
Glarea lozoyensis
pneumocandin B0
Online Access:https://www.frontiersin.org/article/10.3389/fmicb.2018.02788/full

Internet

https://www.frontiersin.org/article/10.3389/fmicb.2018.02788/full

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