Population Pharmacokinetics and Pharmacodynamics Modeling of Torasemide and Furosemide After Oral Repeated Administration in Healthy Dogs

Population Pharmacokinetics and Pharmacodynamics Modeling of Torasemide and Furosemide After Oral Repeated Administration in Healthy Dogs

Torasemide is a loop diuretic licensed in dogs for cardiogenic pulmonary oedema. The aim of this pharmacokinetic-pharmacodynamic (PK/PD) study was to define an optimally effective dosage regimen based on preclinical data. In a first study, 5 dogs received once-daily oral torasemide (0, 0.1, 0.2, 0.4...

Full description

Bibliographic Details
Main Authors: Ludovic Pelligand, Emilie Guillot, Anne Geneteau, Jerome Guyonnet, Reynald Magnier, Jonathan Elliott, Mathieu Peyrou, Matthieu Jacobs
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-04-01
Series:Frontiers in Veterinary Science
Subjects:
loop-diuretic
natriuresis
diuresis
urine
Non Linear Mixed Effect Model (NLME)
aldosterone
Online Access:https://www.frontiersin.org/article/10.3389/fvets.2020.00151/full

Internet

https://www.frontiersin.org/article/10.3389/fvets.2020.00151/full

Similar Items