Therapeutic potential of a novel semi-synthetic-sulfated-polysaccharide to suppress inflammatory mediators in P. gingivalis LPS stimulated human monocytes/macrophages

Abstract Background Chronic periodontitis is associated with an increased risk for systemic conditions such as cardiovascular disease, diabetes, and osteoporosis. During chronic periodontitis, endotoxin (lipopolysaccharide, LPS) produced by P. gingivalis provokes monocyte accumulation and differenti...

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Bibliographic Details
Main Authors: Ying Gu, Veena Raja, Hsi-Ming Lee, Houlin Hong, Glenn Prestwich, Maria E. Ryan
Format: Article
Language:English
Published: BMC 2021-09-01
Series:Journal of Inflammation
Subjects:
Online Access:https://doi.org/10.1186/s12950-021-00292-6