Inhibition of Brd4 by JQ1 Promotes Functional Recovery From Spinal Cord Injury by Activating Autophagy

Spinal cord injury (SCI) is a destructive neurological disorder that is characterized by impaired sensory and motor function. Inhibition of bromodomain protein 4 (Brd4) has been shown to promote the maintenance of cell homeostasis by activating autophagy. However, the role of Brd4 inhibition in SCI...

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Bibliographic Details
Main Authors: Yao Li, Jie Xiang, Jing Zhang, Jiahao Lin, Yaosen Wu, Xiangyang Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-09-01
Series:Frontiers in Cellular Neuroscience
Subjects:
JQ1
Online Access:https://www.frontiersin.org/article/10.3389/fncel.2020.555591/full