The Influence of Chitosan Cross-linking on the Properties of Alginate Microparticles with Metformin Hydrochloride—In Vitro and In Vivo Evaluation

The Influence of Chitosan Cross-linking on the Properties of Alginate Microparticles with Metformin Hydrochloride—In Vitro and In Vivo Evaluation

Sodium alginate is a polymer with unique ability to gel with different cross-linking agents in result of ionic and electrostatic interactions. Chitosan cross-linked alginate provides improvement of swelling and mucoadhesive properties and might be used to design sustained release dosage forms. There...

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Bibliographic Details
Main Authors: Marta Szekalska, Katarzyna Sosnowska, Agnieszka Zakrzeska, Irena Kasacka, Alicja Lewandowska, Katarzyna Winnicka
Format: Article
Language:English
Published: MDPI AG 2017-01-01
Series:Molecules
Subjects:
alginate
chitosan
cross-linking
microparticles
spray drying
hypoglycemic activity
metformin hydrochloride
toxicity
Online Access:http://www.mdpi.com/1420-3049/22/1/182

Internet

http://www.mdpi.com/1420-3049/22/1/182

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