α-Synuclein pathology in Parkinson disease activates homeostatic NRF2 anti-oxidant response

α-Synuclein pathology in Parkinson disease activates homeostatic NRF2 anti-oxidant response

Abstract Circumstantial evidence points to a pathological role of alpha-synuclein (aSyn; gene symbol SNCA), conferred by aSyn misfolding and aggregation, in Parkinson disease (PD) and related synucleinopathies. Several findings in experimental models implicate perturbations in the tissue homeostatic...

Full description

Bibliographic Details
Main Authors: Alberto Delaidelli, Mette Richner, Lixiang Jiang, Amelia van der Laan, Ida Bergholdt Jul Christiansen, Nelson Ferreira, Jens R. Nyengaard, Christian B. Vægter, Poul H. Jensen, Ian R. Mackenzie, Poul H. Sorensen, Asad Jan
Format: Article
Language:English
Published: BMC 2021-06-01
Series:Acta Neuropathologica Communications
Subjects:
Parkinson disease
Alpha-synuclein
Oxidative stress
NRF2
Online Access:https://doi.org/10.1186/s40478-021-01209-3

Internet

https://doi.org/10.1186/s40478-021-01209-3

Similar Items