Cysteine oxidation triggers amyloid fibril formation of the tumor suppressor p16INK4A

Cysteine oxidation triggers amyloid fibril formation of the tumor suppressor p16INK4A

The tumor suppressor p16INK4A induces cell cycle arrest and senescence in response to oncogenic transformation and is therefore frequently lost in cancer. p16INK4A is also known to accumulate under conditions of oxidative stress. Thus, we hypothesized it could potentially be regulated by reversible...

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Bibliographic Details
Main Authors: Christoph Göbl, Vanessa K. Morris, Loes van Dam, Marieke Visscher, Paulien E. Polderman, Christoph Hartlmüller, Hesther de Ruiter, Manuel Hora, Laura Liesinger, Ruth Birner-Gruenberger, Harmjan R. Vos, Bernd Reif, Tobias Madl, Tobias B. Dansen
Format: Article
Language:English
Published: Elsevier 2020-01-01
Series:Redox Biology
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231719307918

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http://www.sciencedirect.com/science/article/pii/S2213231719307918

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