Suppression of the synaptic localization of a subset of proteins including APP partially ameliorates phenotypes of the Drosophila Alzheimer's disease model.

Suppression of the synaptic localization of a subset of proteins including APP partially ameliorates phenotypes of the Drosophila Alzheimer's disease model.

APP (amyloid precursor protein), the causative molecule of Alzheimer's disease, is synthesized in neuronal cell bodies and subsequently transported to synapses. We previously showed that the yata gene is required for the synaptic transport of the APP orthologue in Drosophila melanogaster. In th...

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Bibliographic Details
Main Authors: Koto Furotani, Keisuke Kamimura, Takaaki Yajima, Minoru Nakayama, Rena Enomoto, Takuya Tamura, Hitoshi Okazawa, Masaki Sone
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2018-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC6143267?pdf=render

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http://europepmc.org/articles/PMC6143267?pdf=render

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