Receptor activator of NF-kB (RANK) expression in primary tumors associates with bone metastasis occurrence in breast cancer patients.

Receptor activator of NF-kB (RANK) expression in primary tumors associates with bone metastasis occurrence in breast cancer patients.

<h4>Background</h4>Receptor activator of NFkB (RANK), its ligand (RANKL) and the decoy receptor of RANKL (osteoprotegerin, OPG) play a pivotal role in bone remodeling by regulating osteoclasts formation and activity. RANKL stimulates migration of RANK-expressing tumor cells in vitro, con...

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Main Authors: Daniele Santini, Gaia Schiavon, Bruno Vincenzi, Laura Gaeta, Francesco Pantano, Antonio Russo, Cinzia Ortega, Camillo Porta, Sara Galluzzo, Grazia Armento, Nicla La Verde, Cinzia Caroti, Isabelle Treilleux, Alessandro Ruggiero, Giuseppe Perrone, Raffaele Addeo, Philippe Clezardin, Andrea Onetti Muda, Giuseppe Tonini
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-04-01
Series:PLoS ONE
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21559440/pdf/?tool=EBI

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https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21559440/pdf/?tool=EBI

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