Systemic DKK1 neutralization enhances human adipose‐derived stem cell mediated bone repair

Systemic DKK1 neutralization enhances human adipose‐derived stem cell mediated bone repair

Abstract Progenitor cells from adipose tissue are able to induce bone repair; however, inconsistent or unreliable efficacy has been reported across preclinical and clinical studies. Soluble inhibitory factors, such as the secreted Wnt signaling antagonists Dickkopf‐1 (DKK1), are expressed to variabl...

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Bibliographic Details
Main Authors: Stefano Negri, Yiyun Wang, Takashi Sono, Qizhi Qin, Ginny Ching‐Yun Hsu, Masnsen Cherief, Jiajia Xu, Seungyong Lee, Robert J. Tower, Victoria Yu, Abhi Piplani, Carolyn A. Meyers, Kristen Broderick, Min Lee, Aaron W. James
Format: Article
Language:English
Published: Wiley 2021-04-01
Series:Stem Cells Translational Medicine
Subjects:
adipose stem cell
adipose stromal cell
bone healing
bone repair
bone tissue engineering
mesenchymal stem cell
Online Access:https://doi.org/10.1002/sctm.20-0293

Internet

https://doi.org/10.1002/sctm.20-0293

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