Astragaloside-IV prevents acute kidney injury and inflammation by normalizing muscular mitochondrial function associated with a nitric oxide protective mechanism in crush syndrome rats

Astragaloside-IV prevents acute kidney injury and inflammation by normalizing muscular mitochondrial function associated with a nitric oxide protective mechanism in crush syndrome rats

Abstract Background Crush syndrome (CS) is a serious medical condition characterized by muscle cell damage resulting from decompression after compression (i.e., ischemia/reperfusion injury). A large number of CS patients develop cardiac failure, kidney dysfunction, and systemic inflammation, even wh...

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Bibliographic Details
Main Authors: Isamu Murata, Yuji Abe, Yuka Yaginuma, Kayako Yodo, Yuka Kamakari, Yurika Miyazaki, Daichi Baba, Yuko Shinoda, Toru Iwasaki, Kunihiko Takahashi, Jun Kobayashi, Yutaka Inoue, Ikuo Kanamoto
Format: Article
Language:English
Published: SpringerOpen 2017-09-01
Series:Annals of Intensive Care
Subjects:
Crush syndrome
Astragaloside-IV
Nitric oxide
Fluid resuscitation
Acute kidney injury
Anti-inflammatory
Online Access:http://link.springer.com/article/10.1186/s13613-017-0313-2

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http://link.springer.com/article/10.1186/s13613-017-0313-2

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