Extracellular heat shock protein 90α mediates HDM-induced bronchial epithelial barrier dysfunction by activating RhoA/MLC signaling

Extracellular heat shock protein 90α mediates HDM-induced bronchial epithelial barrier dysfunction by activating RhoA/MLC signaling

Abstract Background The disruption and hyperpermeability of bronchial epithelial barrier are closely related to the pathogenesis of asthma. House dust mite (HDM), one of the most important allergens, could increase the airway epithelial permeability. Heat shock protein (Hsp) 90α is also implicated i...

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Bibliographic Details
Main Authors: Hang-ming Dong, Yan-qing Le, Yan-hong Wang, Hai-jin Zhao, Chao-wen Huang, Ya-hui Hu, Li-shan Luo, Xuan Wan, Yi-lan Wei, Zi-qiang Chu, Wei Li, Shao-xi Cai
Format: Article
Language:English
Published: BMC 2017-05-01
Series:Respiratory Research
Subjects:
Bronchial epithelial
Barrier dysfunction
Extracellular heat shock protein90α
RhoA/MLC signaling
House dust mite
Online Access:http://link.springer.com/article/10.1186/s12931-017-0593-y

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http://link.springer.com/article/10.1186/s12931-017-0593-y

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