Evaluation and Optimization of the Anti-Melanogenic Activity of 1-(2-Cyclohexylmethoxy-6-hydroxy-phenyl)-3-(4-hydroxymethyl-phenyl)-propenone Derivatives

Evaluation and Optimization of the Anti-Melanogenic Activity of 1-(2-Cyclohexylmethoxy-6-hydroxy-phenyl)-3-(4-hydroxymethyl-phenyl)-propenone Derivatives

The chemical modification and optimization of biologically active compounds are essential steps in the identification of promising lead compounds for drug development. We previously reported the anti-melanogenic activity of 1-(2-cyclohexylmethoxy-6-hydroxy-phenyl)-3-(4-hydroxymethyl-phenyl)-propenon...

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Bibliographic Details
Main Authors: Byung-Hak Kim, Soo-Nam Hong, Sang-Kyu Ye, Jung-Youl Park
Format: Article
Language:English
Published: MDPI AG 2019-04-01
Series:Molecules
Subjects:
alpha-melanocyte stimulating hormone (α-MSH)
chalcone
melanin biosynthesis
(<i>E</i>)-<i>N</i>-(4-(3-(2-(cyclohexylmethoxy)phenyl)-3-oxoprop-1-en-1-yl)phenyl)acetamide (chalcone 21-21)
tyrosinase
Online Access:https://www.mdpi.com/1420-3049/24/7/1372

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https://www.mdpi.com/1420-3049/24/7/1372

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