Magnesium Hydroxide Nanoparticles Improve the Ocular Hypotensive Effect of Twice Daily Topical Timolol Maleate in Healthy Dogs

Magnesium Hydroxide Nanoparticles Improve the Ocular Hypotensive Effect of Twice Daily Topical Timolol Maleate in Healthy Dogs

Timolol maleate (TM), a beta-adrenergic receptor antagonist, is widely used for canine antiglaucoma eye drops; however, its bioavailability is <5%. Our previous study revealed that magnesium hydroxide nanoparticles (nMH) have potency in improving the bioavailability of fixed-combined TM in rodent...

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Bibliographic Details
Main Authors: Mizuki Kita, Kazutaka Kanai, Hiroki Mitsuhashi, Tomoki Noguchi, Noriaki Nagai, Mizuki Yamaguchi, Yuya Otaka, Rina Kudo, Yohei Yamashita, Kazuki Tajima
Format: Article
Language:English
Published: MDPI AG 2021-08-01
Series:Veterinary Sciences
Subjects:
dogs
drug delivery system
glaucoma
magnesium hydroxide nanoparticles
timolol maleate
Online Access:https://www.mdpi.com/2306-7381/8/8/168

Internet

https://www.mdpi.com/2306-7381/8/8/168

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