Synthesis of novel 2-(piperazino-1-yl-alkyl)-1H-benzimidazole derivates and assessment of their interactions with the D2 dopamine receptor

Synthesis of novel 2-(piperazino-1-yl-alkyl)-1H-benzimidazole derivates and assessment of their interactions with the D2 dopamine receptor

A total of 14 novel arylpiperazines were synthesized, and pharmacologically evaluated by measuring their affinities towards the D2 dopamine receptor (DRD2) in a [3H]spiperone competition assay. All the herein described compounds consist of a benzimidazole moiety connected to N-(2-methoxyphenyl)piper...

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Bibliographic Details
Main Authors: Penjišević Jelena Z., Andrić Deana B., Šukalović Vladimir B., Roglić Goran M., Šoškić Vukić, Kostić-Rajačić Slađana V.
Format: Article
Language:English
Published: Serbian Chemical Society 2019-01-01
Series:Journal of the Serbian Chemical Society
Subjects:
arylpiperazines
molecular dynamics
molecular docking
receptor binding site
Online Access:http://www.doiserbia.nb.rs/img/doi/0352-5139/2019/0352-51391800104P.pdf

Internet

http://www.doiserbia.nb.rs/img/doi/0352-5139/2019/0352-51391800104P.pdf

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