Iron source preference and regulation of iron uptake in Cryptococcus neoformans.

The level of available iron in the mammalian host is extremely low, and pathogenic microbes must compete with host proteins such as transferrin for iron. Iron regulation of gene expression, including genes encoding iron uptake functions and virulence factors, is critical for the pathogenesis of the...

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Bibliographic Details
Main Authors: Won Hee Jung, Anita Sham, Tianshun Lian, Arvinder Singh, Daniel J Kosman, James W Kronstad
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2008-02-01
Series:PLoS Pathogens
Online Access:http://europepmc.org/articles/PMC2242830?pdf=render