Generation of human induced pluripotent stem cells from individuals with a homozygous CCR5Δ32 mutation

Generation of human induced pluripotent stem cells from individuals with a homozygous CCR5Δ32 mutation

Chemokine receptor 5 (CCR5) is the primary coreceptor for HIV entry into macrophages. Individuals with a homozygous deletion of 32 bp in the CCR5 gene (CCR5Δ32) are highly resistant to HIV infection (Samson et al., 1996). Allogeneic stem cell transplantation from a healthy donor with the homozygous...

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Main Authors: Guibin Chen, Hui Jin, Zhen Yu, Yangtengyu Liu, Zhongwen Li, Keron Navarengom, Robin Schwartzbeck, Natalia Dmitrieva, Cornelia Cudrici, Elisa A. Ferrante, Leslie G. Biesecker, Dan Yang, Manfred Boehm
Format: Article
Language:English
Published: Elsevier 2019-07-01
Series:Stem Cell Research
Online Access:http://www.sciencedirect.com/science/article/pii/S1873506119301114

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http://www.sciencedirect.com/science/article/pii/S1873506119301114

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