Physiopathological Role of the Vesicular Nucleotide Transporter (VNUT) in the Central Nervous System: Relevance of the Vesicular Nucleotide Release as a Potential Therapeutic Target

Physiopathological Role of the Vesicular Nucleotide Transporter (VNUT) in the Central Nervous System: Relevance of the Vesicular Nucleotide Release as a Potential Therapeutic Target

Vesicular storage of neurotransmitters, which allows their subsequent exocytotic release, is essential for chemical transmission in the central nervous system. Neurotransmitter uptake into secretory vesicles is carried out by vesicular transporters, which use the electrochemical proton gradient gene...

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Bibliographic Details
Main Authors: María T. Miras-Portugal, Aida Menéndez-Méndez, Rosa Gómez-Villafuertes, Felipe Ortega, Esmerilda G. Delicado, Raquel Pérez-Sen, Javier Gualix
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-05-01
Series:Frontiers in Cellular Neuroscience
Subjects:
VNUT
vesicular ATP release
purinergic signaling
neuropathic pain
glaucoma
clodronate
Online Access:https://www.frontiersin.org/article/10.3389/fncel.2019.00224/full

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https://www.frontiersin.org/article/10.3389/fncel.2019.00224/full

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