Mitochondrial DNA damage associated with lipid peroxidation of the mitochondrial membrane induced by Fe2+-citrate

Mitochondrial DNA damage associated with lipid peroxidation of the mitochondrial membrane induced by Fe2+-citrate

Iron imbalance/accumulation has been implicated in oxidative injury associated with many degenerative diseases such as hereditary hemochromatosis, beta-thalassemia, and Friedreich's ataxia. Mitochondria are particularly sensitive to iron-induced oxidative stress - high loads of iron cause exten...

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Bibliographic Details
Main Authors: Andréa M. Almeida, Clélia R.A. Bertoncini, Jiri Borecký, Nadja C. Souza-Pinto, Aníbal E. Vercesi
Format: Article
Language:English
Published: Academia Brasileira de Ciências 2006-09-01
Series:Anais da Academia Brasileira de Ciências
Subjects:
ferro
peroxidação lipídica
mitocôndrias
DNAmt
estresse oxidativo
iron
lipid peroxidation
mitochondria
mtDNA
oxidative stress
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652006000300010

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