iPSC-Derived Regulatory Dendritic Cells Inhibit Allograft Rejection by Generating Alloantigen-Specific Regulatory T Cells

iPSC-Derived Regulatory Dendritic Cells Inhibit Allograft Rejection by Generating Alloantigen-Specific Regulatory T Cells

Regulatory dendritic cell (DCregs)-based immunotherapy is a potential therapeutic tool for transplant rejection. We generated DCregs from murine induced pluripotent stem cells (iPSCs), which could remain in a “stable immature stage” even under strong stimulation. Harnessing this characteristic, we h...

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Bibliographic Details
Main Authors: Songjie Cai, Jiangang Hou, Masayuki Fujino, Qi Zhang, Naotsugu Ichimaru, Shiro Takahara, Ryoko Araki, Lina Lu, Ji-Mei Chen, Jian Zhuang, Ping Zhu, Xiao-Kang Li
Format: Article
Language:English
Published: Elsevier 2017-05-01
Series:Stem Cell Reports
Subjects:
iPSC
regulatory dendritic cells
regulatory T cells
antigen-specific tolerance
murine cardiac allotransplant
TGF-β1
Online Access:http://www.sciencedirect.com/science/article/pii/S2213671117301261

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http://www.sciencedirect.com/science/article/pii/S2213671117301261

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