Analysis of Immune Landscape Reveals Prognostic Significance of Cytotoxic CD4+ T Cells in the Central Region of pMMR CRC

Analysis of Immune Landscape Reveals Prognostic Significance of Cytotoxic CD4+ T Cells in the Central Region of pMMR CRC

BackgroundMismatch repair proficient colorectal cancer (pMMR CRC) lacks effective treatments and has a poor prognosis, which can be attributed to the complexity of tumor microenvironment. The coordinated function of immune cells is vital to anti-tumor immunity. However, the spatial characteristics o...

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Bibliographic Details
Main Authors: Jingwen Qi, Xiaoyan Liu, Peian Yan, Shangwen He, Yuhao Lin, Zhiwei Huang, Shenyan Zhang, Siyu Xie, Yanfeng Li, Xiaofei Lu, Yingjun Wu, Yangshu Zhou, Juanjuan Yuan, Ting Cai, Xiaojun Zheng, Yanqing Ding, Wei Yang
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-09-01
Series:Frontiers in Oncology
Subjects:
mismatch repair-proficient colorectal cancer
multiplex immunohistochemistry
tumor infiltrating lymphocytes
tumor immune microenvironment
neoadjuvant chemotherapy
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2021.724232/full

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https://www.frontiersin.org/articles/10.3389/fonc.2021.724232/full

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