ATM activation accompanies histone H2AX phosphorylation in A549 cells upon exposure to tobacco smoke

<p>Abstract</p> <p>Background</p> <p>In response to DNA damage or structural alterations of chromatin, histone H2AX may be phosphorylated on <it>Ser</it>139 by phosphoinositide 3-kinase related protein kinases (PIKKs) such as <it>ataxia telangiectasia...

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Bibliographic Details
Main Authors: Traganos Frank, Gietl Diana, Jorgensen Ellen, Huang Xuan, Tanaka Toshiki, Darzynkiewicz Zbigniew, Albino Anthony P
Format: Article
Language:English
Published: BMC 2007-06-01
Series:BMC Cell Biology
Online Access:http://www.biomedcentral.com/1471-2121/8/26