Ceapins are a new class of unfolded protein response inhibitors, selectively targeting the ATF6α branch

Ceapins are a new class of unfolded protein response inhibitors, selectively targeting the ATF6α branch

The membrane-bound transcription factor ATF6α plays a cytoprotective role in the unfolded protein response (UPR), required for cells to survive ER stress. Activation of ATF6α promotes cell survival in cancer models. We used cell-based screens to discover and develop Ceapins, a class of pyrazole amid...

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Bibliographic Details
Main Authors: Ciara M Gallagher, Carolina Garri, Erica L Cain, Kenny Kean-Hooi Ang, Christopher G Wilson, Steven Chen, Brian R Hearn, Priyadarshini Jaishankar, Andres Aranda-Diaz, Michelle R Arkin, Adam R Renslo, Peter Walter
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2016-07-01
Series:eLife
Subjects:
endoplasmic reticulum
unfolded protein response
small molecule screening
ATF6-alpha
site-1-protease
ER to Golgi trafficking
Online Access:https://elifesciences.org/articles/11878

Internet

https://elifesciences.org/articles/11878

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