Localization of <sup>99m</sup>Tc-GRP Analogs in GRPR-Expressing Tumors: Effects of Peptide Length and Neprilysin Inhibition on Biological Responses

Localization of <sup>99m</sup>Tc-GRP Analogs in GRPR-Expressing Tumors: Effects of Peptide Length and Neprilysin Inhibition on Biological Responses

The overexpression of gastrin-releasing peptide receptors (GRPRs) in frequently occurring human tumors has provided the opportunity to use bombesin (BBN) analogs as radionuclide carriers to cancer sites for diagnostic and therapeutic purposes. We have been alternatively exploring human GRP motifs of...

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Bibliographic Details
Main Authors: Aikaterini Kaloudi, Emmanouil Lymperis, Panagiotis Kanellopoulos, Beatrice Waser, Marion de Jong, Eric P. Krenning, Jean Claude Reubi, Berthold A. Nock, Theodosia Maina
Format: Article
Language:English
Published: MDPI AG 2019-03-01
Series:Pharmaceuticals
Subjects:
bombesin
gastrin-releasing peptide
gastrin-releasing peptide receptor
tumor targeting
<sup>99m</sup>Tc-radioligand
metabolic stability
neprilysin-inhibition
phosphoramidon
Online Access:https://www.mdpi.com/1424-8247/12/1/42

Internet

https://www.mdpi.com/1424-8247/12/1/42

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